Publication – Fluorination reactions in microreactors

Chem. Commun., 2008, 3022-3024

• Tomas Gustafsson, Ryan Gilmour, and Peter H. Seeberger*
• Swiss Federal Institute of Technology, Zurich, Laboratorium für Organische Chemie, Switzerland

This paper describes a fast, safe and continuous fluorination protocol using DAST for primary alcohols, carboxylic acids, and aldehydes conducted in a Syrris Tube Reactor on a Syrris FRX system (now replaced by Asia).

Abstract: The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale.

This paper used an FRX flow chemistry system (now replaced by Asia).