What is Log D?

Log D is the ratio of the equilibrium concentrations of all species (unionized and ionized) of a molecule in octanol compared to same species in the aqueous phase at a standard temperature (normally 25° C). It differs from LogP in that ionized species are considered as well as the neutral form of the molecule.

LogD is defined as:

Where the sum is over all species (C) and the subscripts oct and aq refer to concentrations in the aqueous and organic phases.

Syrris utilize FLLEX within an Asia system to separate the aqueous and octanol phases after partitioning between the phases is complete.

Click here to see the Asia flow system.

For more information about this application, please contact us.