The Syrris range of batch and flow chemistry products has been used in a number of cutting-edge studies and scientific breakthroughs. Below is a list of publications involving discovery chemistry performed with our products.
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Continuous Flow Polymer Synthesis toward Reproducible Large-Scale Production for Efficient Bulk Heterojunction Organic Solar Cells
Product used: Asia Flow Chemistry System and the Asia FLUX
This paper describes the conversion of a batch process into a continuous flow process for carrying out a complex Stille polycondensation reaction.
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Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions
Product used: Asia Syringe Pumps
This paper published by Oliver Kappe’s group from the University of Graz, in collaboration with Lonza and AstraZeneca, focuses on an efficient flow protocol for the synthesis of sulfoximine.
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Synthesis of 4 Substituted Phthalazin-1(2H) ones from 2 Acylbenzoic Acids
Product used: Asia Syringe Pumps
This paper published by Oliver Kappe’s group from the University of Graz, in collaboration with Lonza and AstraZeneca, focuses on an efficient flow protocol for the synthesis of sulfoximine.
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A Ugi Multicomponent Azide−Alkyne Cycloaddition Approach for the Generation of Cyclic Peptoids
Product used: Asia Flow Chemistry System
Using a Syrris Asia flow chemistry system researchers at the University of Graz and Universidade de Brasilia have demonstrated a complex, multi-step continuous synthesis of cyclic peptoids using a sequential Ugi multicomponent/Cu-catalysed Azide-Alkyne cycloaddition approach.
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The Use of Flow Chemistry for Two-Phase Dibromocyclopropanation of Alkenes
Product used: Asia Flow Chemistry System and the Asia Glass Microreactor
Using a Syrris flow system and glass microreactors, researchers at the Norwegian University of Life Sciences and SINTEF Materials and Chemistry have demonstrated a novel method for the dibromo-cyclopropanation of alkenes via a continuous two-phase method.
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Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
Product used: Asia Flow Chemistry System
Using the Syrris Asia flow chemistry system researchers at the Universidade Federal do Rio de Janeiro have demonstrated an interesting alternative on the bioreduction of ?-ketoesters by immobilized microorganisms.
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Continuous Metal Scavenging and Coupling to One-Pot Copper-Catalyzed Azide-Alkyne Cycloaddition "Click" Reaction in Flow
Product used: Asia FLLEX
Using the Syrris Asia FLLEX (Flow Liquid Liquid Extraction) module researchers at the Eindhoven University of Technology have demonstrated an efficient extraction method to continuously remove metal catalysts from an azide-alkyne cycloaddition click reaction in flow.
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Ammonium formate as a green hydrogen source for clean semi-continuous enzymatic dynamic kinetic resolution of (+/-)-α-methylbenzylamine
Product used: Asia Syringe Pump and Asia Solid Phase Reactor
This paper describes a new, semi-continuous method for the dynamic resolution of (+/-)-?-methylbenzylamine utilizing Pd/BaSO4 as racemisation catalyst and ammonium formate as a green reducing agent whilst utilizing Novozyme 235 in an immobilized form for the kinetic resolution.
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Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis
Product used: Asia FLUX
This paper aims to close the knowledge gap between microfluidic synthetic organic chemistry and optimized microfluidic organic electrosynthesis. This paper describes the optimization of a previously characterized anodic methoxylation reaction in respect to charge efficiency, selectivity, conversion and product formation rate with the fractional conversion rate being dramatically increased.
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Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry
Product used: Asia FLUX
This paper describes the use Syrris’s Asia Flux module to achieve full natural product synthesis of Nazlinine.
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Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry
Product used: Asia Flow Chemistry System
Eight years after its pioneering paper on the multi-step synthesis of the oxomaritidine in flow, Steve Ley’s group publishes a new groundbreaking paper describing the total synthesis of natural products Spirodienal A and Spirangien A. The authors describe the complex synthesis of two key building blocks, where most of the 20+ steps are conducting in continuous flow, then the subsequent reactions leading to the final spirocyclic products.
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Ultrafast polymerization with high throughput and low polydispersity index
Product used: Asia Flow Chemistry System
This paper describes a continuous process for the synthesis of poly(3-hexylthiophene). The authors have improved on the traditional batch Grignard Metathesis polymerization reaction by identifying a solvent which dissolves the catalyst.
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The Methoxylation of N-formylpyrrolidine in a Microfluidic Electrolysis Cell for Routine Synthesis
Product used: Asia Flow Chemistry Systemand Asia FLUX
This paper describes the application development of a high-yielding, high-throughput N-formyl-pyrrolidine methoxylation reaction carried out in a flow electrochemical cell.
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TEMPO-Mediated Electrooxidation of Primary and Secondary Alcohols in a Microfluidic Electrolytic Cell
Product used: Asia Flow Chemistry System and Asia FLUX
This paper describes a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) catalysed electro-oxidation of a range of 15 primary and secondary alcohols to the corresponding aldehyde or ketone at ambient temperatures.
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Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry
Product used: Asia Flow Chemistry System and Asia FLUX
This paper describes the evaluation and use of the FLUX microfluidic electrochemical cell.
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Preparative Microfluidic Electrosynthesis of Drug Metabolites
Product used: Asia Flow Chemistry System and Asia FLUX
This paper describes the preparative electrochemical synthesis of phase I and phase II metabolites of a range of commercial drug molecules. In this study the Flux module is utilised to replicate hepatic oxidation, whilst maintaining high throughput at the preparative scale (100mg/hr) generating a range of phase I metabolites and Phase II Glutathione adducts on a range of commercially available drug molecules, therefore enabling full structural elucidation of these metabolites to be carried out by NMR (1D and 2D).
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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir
Product used: Asia Flow Chemistry System and Asia Syringe Pumps
This paper describes a three-step process in flow for the synthesis of a key building block for the drug Atazanavir. The process includes a Suzuki coupling, a hydrazone formation and a hydrogenation.
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Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry
Product used: Asia Flow Chemistry System
This paper describes the use of immobilised squaramide catalysts for Michael additions. The organocatalysts were packed in glass columns and used on an Asia system in a continuous flow fashion to achieve Michael reactions with a wide range of substrates.
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Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions
Product used: Asia Flow Chemistry System
This paper describes the microfluidic optimisation of a two-step strategy for the manufacture of a range of bicyclodecanes with six contiguous stereogenic centres. This paper further describes the optimisation of an organocatalysed Michael addition, giving highly diastereoselective ?-nitroketones which were further telescoped into a nitro-Michael-aldol reaction to yield the bicyclo[4.4.0]decanes with enantiomeric ratios of up to 89:11.
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Silver nanowires and nanoparticles from a microfluidic reactor: application to metal assisted silicon etching
Product used: Asia Flow Chemistry System and Asia Syringe Pumps
This paper studies the synthesis of silver nanoparticle. Thanks to the Asia Flow Chemistry system and Asia Syringe Pumps, the authors were able to quickly run a set of reactions and indentify the optimized conditions for the formation of silver nanowires.
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Nickel nanocrystals: fast synthesis of cubes, pyramids and tetrapods
Product used: Asia Syringe Pump and a glass microreactor
In this paper, the authors study the formation and growth of nickel nanocrystals / nanoparticles using organometallic Ni(?4-C8H12)2 as a precursor. The reaction temperature has been identified as the key parameter which determines the shape of the obtained nanoparticles.
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Hydrogen-Free Alkene Reduction in Continuous Flow
Product used: Asia Flow Chemistry System
This paper from the prestigious Massachusetts Institute of Technology reports the first continuous flow method for hydrogen free hydrogenation via diimide (diazine, HN=NH) generated in situ by a novel reagent combination.
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Greening heterogeneous catalysis for fine chemicals
Product used: Asia Flow Chemistry System
This paper describes how flow chemistry can be successfully used to enhance heterogeneous catalytic reactions. A series of C-C Suzuki Miyaura coupling reactions using different aryl halide substrates are optimized on an Asia 220 system.
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A Computer-Controlled Biodiesel Experiment
Product used: Orb
Biodiesel is fast becoming an increasingly popular alternative to petroleum based fuels. This paper describes a fully automated base-catalyzed transesterification process to produce biodiesel from vegetable oil.
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Continuous flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline
Product used: Asia Flow Chemistry System
This paper describes a versatile enantioselective ?-aminoxylation process in flow using a solid supported catalyst. The use of flow chemistry allows improved conversion rates thanks to the high contact surface between reagent and catalyst and also simplifies the scale-up of this reaction.
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Continuous Flow Synthesis of n-Alkyl Chlorides in a High-Temperature Microreactor Environment
Product used: Asia Flow Chemistry System and Asia Microreactors
This paper describes a continuous process for chlorination of alcohols. Originally optimised for microwave, the process was seamlessly transferred to an Asia flow chemistry system in order to scale up the reaction.
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Liquid-Liquid Two-phase Flow Patterns in a Serpentine Microchannel
Product used: Asia Flow Chemistry System, using Syrris’ FLLEX
The study detailed in this paper focuses on liquid-liquid two-phase flow patterns. It uses a Syrris glass microreactor fitted on a Syrris FRX flow chemistry system (now replaced by Asia) to visually characterize the seven different mixing patterns obtained in a microreactor channel.
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Continuous-flow reactor-based synthesis of carbohydrate and dihydrolipoic acid-capped quantum dots
Product used: Asia Flow Chemistry System
This paper describes a detailed protocol for the synthesis of quantum dots on a Syrris FRX flow chemistry system (now replaced by Asia).
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Enhanced catalysis under flow conditions using SiliaBond functionalized silica gels
Product used: Asia Flow Chemistry System and column reactors
The work published in this paper was performed on an Asia flow chemistry system and shows an improved yield and selectivity with flow chemistry over traditional batch techniques.
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Little Artifices of Huge Libraries: Secrets of Parallel Liquid-Phase Synthesis
Product used: Asia Flow Chemistry System
This paper describes the potential of flow chemistry performed on Syrris’ Africa flow chemistry system (replaced by Asia) and separation performed using Syrris’ FLLEX (Flow Liquid Liquid EXtraction) technology.
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Mesoscale Flow Chemistry: A Plug-Flow Approach to Reaction Optimisation
Product used: Asia Flow Chemistry System
The work published in this paper was performed on an Africa flow chemistry system (now replaced by Asia). The image below shows the formation of an organic reaction plug (orange solution) in a perfluorinated solvent system in 0.75mm i.d. PFA tubing.
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Towards a continuous flow environment for lipase-catalyzed reactions
Product used: Asia Flow Chemistry System
An Asia system is used to enable 60x higher throughput per gram of catalyst than the batch process. The Asia Heater is used to carefully control the temperature of solid supported lipases to, for example, esterify a chiral alcohol in the field of sugar based surfactants.
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Copper(I)-Catalyzed Azide–Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit
Product used: Asia Flow Chemistry System and the Asia FLLEX
The Asia FLLEX module was used as a copper scavenging/extracting unit.
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Fluorination reactions in microreactors
Product used: Asia Flow Chemistry System
This paper describes a fast, safe and continuous fluorination protocol using DAST for primary alcohols, carboxylic acids, and aldehydes conducted in a Syrris Tube Reactor on a Syrris FRX system (now replaced by Asia).
